Work with the difference in structure between fungal and human cell membranes. Examine that fungal cell membranes utilize the steroid ergosterol to five the membrane physical stability, while humans membranes utilize cholesterol. Place both structural formulas on the skin, and note the very, very, close chemical relationship.
Discuss how two classes of fungicides will interfere with the ergosterol synthesis, being ergosterol cell membrane inhibitors.
Cholesterol does not have the same affinity for the inhibitor and therefore the host cells are not as easily damaged.
View a short pharmacology video which outlines and reinforces the pharmacology behind the anti fungals.