Discuss drug metabolism paper handed in on Monday.
Introduce antimicrobials and antineoplastic.
Discus how the etiology may be different, but from a pharmacological perspective, the principles of treatment are the same.
Discuss the common thread, the targeting of selective differences between the microbe and cancer cell and the normal host cell.
Stress that the goal of treatment is complete inhibition of growth of the microbe and cancer cell.

View and discuss a pharmacokinetic video which examines and explains phase 1 and phase 2 metabolism of drugs. The video discusses the polymorphic liver enzymes, the conversion of active into inactive drug, the conversion of prodrug into active drug, and the conversion of active drug into toxic drug.
The increase in solubility brought about by phase 2 metabolism, allowing for excretion was explained.

Indicate, using diagrams and examples, how some drugs are affected by whether their metabolic enzymes are activated or inhibited.
Show how toxicity can increase if an enzyme inhibitor drug is administered along with an active drug or metabolite.
Discuss methanol metabolism, the enzyme required, and ethanol metabolism.
Show how when toxic methyl alcohol is ingested, the ingestion of non toxic ethyl alcohol will compete for the enzyme and prevent the methanol from metabolizing into formaldehyde, which is toxic.

Discuss and explain through case studies the effect race, ethnicity, and genetics has on drug metabolism and dosage.
Concentrate on how a specific genetic mutation can cause respiratory paralysis and death due to the inability to metabolize a specific muscle relaxant.

Discuss the variations in metabolic affects on drugs due to race, gender, and age.
Outline the genetic variations causing these effects and the adjustments in dosing needed to prevent toxicity.
Use examples and case studies.

Review definition of metabolite and prodrug.
Discuss the effects of estrogen on the growth of cancer cells.
Identify the compound Tamoxifen as a selective estrogen receptor modulator.
Outline its effect as an antagonist to specific estrogen receptors, which when it binds, will prevent estrogen from binding to the cancer cells and not allow the cells to receive the signals for growth,
Show with a diagram how the metabolite of Tamoxifen is an active metabolite, about 100x more active than the basic drug.

examine the effects on drug metabolism and activity brought about by inductive and inhibition of metabolic enzymes.
Introduce active and toxic metabolites, along with the term "prodrug".
Using a specific a selective estrogen receptor modulator, Tamoxifen, demonstrate how the metabolic hydroxylation , which occurs within the liver, becomes the active drug and Tamoxifen is the prodrug.
Begin a case study of genetic variability on drug metabolism will affect the activity

Define the terms metabolite and prodrug.
Discuss how drug metabolism can be influenced by the levels of drug metabolizing enzymes.
Define "xenobiotic substance"
Analyze a case study presented in a pharmacology textbook.
Discuss how each drug listed for the patient effected every other drug through the enzyme metabolic system.
Introduce the possibility of a toxic reaction due to metabolic enzyme inhibition exhibited by one of the chemicals.
Discuss how a drug may cause its own metabolic detoxification because it also can be a metabolic enzyme inducer for itself.

Discuss the main liver metabolic enzyme, responsible for 75% of all drug metabolism.
Discuss two other major enzyme pathways, alcohol metabolism by alcohol dehydrogenase enzyme and amine containing neurotransmitters by a monamine oxidase enzyme.
Discuss how metabolic enzyme inducers affect a drug and also how metabolic inhibitors will affect the bioavailability.

Outline and discuss the methods of metabolism of a drug.
Establish that the metabolism represents the next factor, after absorption and distribution, in the determination of a drug's availability and effect.
Concentrate on the liver and the liver enzymes.